Neuroendocrine cancer symptoms. Neuroendocrine cancer with carcinoid syndrome


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One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.

They change related to the disease progression, regardless therapy.

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Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism. We analyzed in a retrospective study of 2 years the dynamic of the NET markers and the glycemia profile. Material and Methods.

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All the patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly.

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The fasting glucose insignificantly changed from baseline after 2 years. No new case of diabetes was registered. One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. The neuron specific enolase significantly increased, and the serum serotonin as well as the 5HIIA was much higher in 2 cases with aggressive neuroendocrine cancer symptoms symptoms.

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The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated. Neuroendocrine tumors.

Endocr Relat Cancer. DOI: Oberndorfer S. Karzinoide tumoren des dunndarms. Frank Z Pathol. Carcinoid Tumors.

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Bellizzi AM. Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnosis immunohistochemistry.

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Adv Anat Pathol. Chromogranins A, B, C: widespread consitituents of secretory vesicles.

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  • Neuroendocrine tumours NETs : symptoms, diagnosis and treatment Duplicate citations This type of cancer has a high mortality, and the overall survival is also low.

Ann N Y Acad Sci. Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. CO; 8.

NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS

Regul Pept. The poor prognosis factors in G2 neuroendocrine tumor. Rom J Morphol Embryol. The dedifferentiation of neuroendocrine tumor metastases: myth or reality? Octreotide for the treatment of hypoglycemia after insulin glargine overdose.

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J Emerg Med. Biochemical testing for neuroendocrine tumors. The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors.

Endocrinol Metab Clin North Neuroendocrine cancer symptoms ;40 1 Well-differentiated neuroendocrine cancer symptoms tumor and osteoporosis: incidental finding? Treatment of malignant midgut carcinoid tumours with a long-acting somatostatin analogue octreotide.

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Acta Oncol. Long-term clinical outcome of somatostatin analogues for treatment of pregressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma. Ann Oncol. Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma.

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