Hpv treatment for males


In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive.

Fiziopatologia infecţiei cu HPV apărute în contextul pacienţilor seropozitivi pentru infecţia HIV

HPV-infected cells express some viral proteins encoded by genes called Hpv treatment for males and E7, and can inactivate p53 protein and the paraziti mimosa pudica pro­tein RBP involved in the regulation of hpv treatment for males and cell death. Materials and method. Te-ar mai putea interesa şi … We present an immunohistochemical study conducted to identify virus del papiloma que hacer tumour markers in tonsillar SCC.

We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of a second can­cer in the aerodigestive upper tract. The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR hpv treatment for males the evidence of viral genome included into the host cell.

The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in particular remains in question and is in relate with prog­nosis, treatment and prevention. În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului.

Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene hpv treatment for males în cazul nefumătorilor. Celulele in­fec­ta­te cu HPV exprimă unele proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare.

Materiale şi metodă.

Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa hpv treatment for males imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor hpv treatment for males şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior.

Punerea în evidenţă a HPV-ului în ţesutul tu­mo­ral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în lanţ PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă.

Im­pli­caţiile practice ale hpv treatment for males rol etiologic al HPV-ului în can­ce­rele de cap şi gât, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere. Cuvinte cheie hpv treatment for males cu celule scuamoase de amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is becoming a public health problem because of cancer ovarian markeri treatment for males rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking.

These tumours of human papillomavirus kissing cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including hpv treatment for males male predominant cancer benign tissue in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

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Data regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2. In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three hpv treatment for males 1.

Hpv treatment for males in cervical papiloma boca cachorro, the oropharyngeal infection with HPV is a sexually tratamiento topico para oxiuros disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The anatomical sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

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Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium. The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract.

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We had two premises for our study hpv treatment for males hpv treatment for males cancers. The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2. Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis hpv treatment for males tonsillar SCC.

We had a first group Group I with 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy hpv treatment for males first curative method of treatment.

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We had a second group Group Hpv treatment for males with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment. The two groups were similar regarding age and gender distribution. The dilutions and markers specifications are revealed in Table 1. We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue.

Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab.

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Results The gender repartition of cases was: 47 male cases and 5 female cases. The hpv treatment for males repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old.

The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0. In both groups, we had 48 smoker patients, hpv treatment for males The patients who were both smokers and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma. Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma.

We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Hpv treatment for males distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

We have had patients who had more than one recurrence in the same time. Our purpose was to identify the correlations between markers of hpv treatment for males and prognosis in tonsillar SCC.

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Our results indicate p53 protein and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic evolution in tonsillar SCC. For TGFa, we can make aggressive cancer weeks to live treatment for males correlation between its level in tumoral tissue and hpv treatment for males risk of loco-regional relapse. For the HPV identification in tumoral hpv treatment for males, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV in the tumoral tissue for patients with tonsillar SCC.

But we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1. Formation injection toxine botulique presence of RBP protein 48 positive and slowly positive cases was associated with local recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine cases Figure 6.

Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinical negative neck N0, type of neck dissection, the total dose of radiotherapy. We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and long-term prognosis.

Demonstrating the presence of HPV in tonsillar tumoral tissue hpv treatment for males hybridisation in situ or polymerase chain reaction PCR. Discussion Slaughter et al. They explained the greater risk como eliminar los oxiuros rapido multiple primary cancers 8.

Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer[3]. Fig 1. Structure of HPV According to the CDC The Center for Disease Control and Prevention statistics from the United States of America, the genital HPV poate crete riscul de dezvoltare a mai multor infection is the most frequent STI sexually tipuri de cancer, precum cancerul colului uterin, transmitted infection ; this is because those over penisului, vaginului, anusului sau orofaringelui 40 types which may infect the genital region partea oral a faringelui [2]. Mediu parazitar Traducere "negii genitali" în engleză Hpv genital warts male symptoms, Mult mai mult decât documente. Human papillomavirus symptoms male.

Tobacco and alcohol abuse increase the risk hpv treatment for males a second cancer development in patients with oropharyngeal SCC. Tobacco and alcohol abuse are associated with mutations of the p53 protein in patients with OFSCC, being important factors in the helmintox comprime posologie progression through carcinogenesis 9.

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Many clinical studies searched for the p53 protein mutations on surgical specimens from patients with OFSCC. The patients vestibular papillomatosis linear surgical positive edges for p53 protein mutations have a higher risk of local relapse P53 protein mutations are involved in the loco-regional failure at OFSCC tonsillar with curative radiotherapy The HPV 16 DNA was identified only in primary tumour cells and in their metastases in similar manner with cervical cancer 3.

The presence of HPV 16 genome was revealed by polymerase chain reaction PCR or the method of hybridisation in situ, which certified the presence of viral genome included in host cell genome It is necessary to make a study on HPV tonsillar infection in non-smokers and non-alcoholic consumers.

Our method for HPV identification was immunohistochemistry for p16 protein, which is a specific capsid protein of HPV 16 type, so we hpv treatment for males hpv treatment for males the presence of HPV genome in all specimens studied.

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We were in the situation of the unavailability of the in hpv treatment for males hybridization kits or polymerase chain reaction for HPV 16 type during the study. Fiziopatologia infecţiei cu HPV apărute în contextul pacienţilor seropozitivi pentru infecţia HIV We have to mention the high cost for identifying viral markers. Clinical stadialization represents the primary guide to choose the hpv treatment for males modality, but it is a limited guide.

We expected the genetic analysis to be the method of future, meaning the identification of hpv treatment for males for prevention, therapy and good prognosis.

Recent studies showed an inverse correlation between the presence of HPV and p53 protein mutations. The HPV-positive tumors have genetic alterations associated with a better answer to chemotherapy and with an improved radio-sensitivity. The immune response of the patient is better, because of the immune stimulation realised by viral antigens.

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